What becomes the broken hearted?

I am fortunate enough to have two best friends: Eloise, who I have known for over 20 years and Hollie who I've known for 15 years. They are the best friends a gal could have. They are my touchstones to sanity when things have been completely out of control in my life.
The differences in our lives have never mattered (we all come from different socioeconomic backgrounds, cultures, religions) until a few years ago when I got married. Eloise had been with her boyfriend at that point for nearly 10 years whereas Hollie had been single for most of the last 10 years with sporadic dating. It took awhile for them to adjust to my life as a married chick but they sprung back. With Eloise, I think it made her a little more aware that her boyfriend's never ending line about how he didn't need a piece of paper to tell the world that he loved her.
Once Boy came along, the divide grew between me and Eloise. It was about that time that Eloise found herself becoming more oppressed by her boyfriend, Ken. Ken is an artist. Or in his mind, an Artist. He does big, expressive canvasses and I think his stuff veers between Jackson Pollock and Matisse. He believes that you give it all for art and you don't take a job to settle. You dedicate yourself to the art - and take side jobs to pay for it until you Hit It Big. So for the last 10 years they've lived in a duplex that looks like it'll collapse in a good earthquake that they bought with money they didn't have scrabbling for the dollars to pay for the mortgage, the various fixes that they patch because if they get just enough to fix it, Ken uses the money to buy something he 'absolutely' needs for his latest art project.
Ken is a good guy but single minded. He is obsessed with his own needs and believes completely in art. I've had some interesting conversations at gallery openings about the art displayed that wasn't his. For some reason, he takes my critiques seriously (maybe because I do know the difference between Monet and Warhol) so he doesn't have a huge problem with my friendship with Eloise. Passion is where he works from - be passionate or don't bother to talk to him.
Eloise is a far less intense individual. She is more of a country mouse to his city mouse. Her art is more on the side of native art. It's very good and better than 90% of the stuff you see at art and wine festivals. She would make more money off it if she would do these festivals but Ken has talked her out of it saying that the art should be in galleries which isn't her cup of tea.
She is also a realist. They have a mortgage and bills plus her 10+ year old car needs hundreds of dollars of work every couple of months. She has a job working at a museum that doesn't cover everything, but it's steady and gives her insurance. Ken thinks she is a sell out. He has gotten angry with her for not telling her bosses that she cannot work on the days of his gallery openings so she can stand by him to tell her that of course, the canvasses will all sell. Which they don't all sell.
In the last three years, Eloise has become distant. I can't get her on the phone more than a couple of times a year. In the last year, I haven't talked to her more than twice. And always when Ken is not home or if she's out running errands. She didn't send a birthday card to me or even a Christmas card. Which is out of character. I figured she had written me off because I had told her that I had my doubts about Ken's relationship with her.
Then she called today. She was grateful that I hadn't written her entirely off. She and Ken were breaking up - but Ken didn't realise it. Ken thinks that the couples therapy they are starting will help her realise how she needed change for their relationship to work. The fact that she has done everything within reason to keep his dream alive is beside the point. Some time this spring, she is going to move out of their duplex but she needs to figure out where she wants to go with her life. Find her path.
What do you tell someone who is just figuring out that she has spent the last 15 years with someone who still doesn't understand her? Who refuses to understand her? Who is still a hurt 14 year old boy who can't understand why his Dad is calling him a 'pansy' for looking at art books rather than building a go cart?
There isn't anything to say. You just have to let them talk to you. Let them come sit on your couch and play with your kid, eat cookies with Coke and say nothing or everything.